A: Bacterial Molecules and Cells
Central question
Which bacterial molecules govern the specific interactions of bacterial cells with other microorganisms and host cells?
Aim
Bacterial fitness and microbial interactions are shaped by multiple factors, including the ability to secrete antimicrobial compounds and to colonize specific niches. Scientists in Research Area A will join forces to identify and isolate from the human microbiome new bacterial strains that produce antimicrobials. The mode of action of these molecules will then be dissected and their ecological role clarified.
In parallel, using a combination of computational, genetic, cellular and biochemical approaches, gene clusters potentially involved in glycopolymer biosynthesis will be identified and their involvement in bacterial adhesion in cooperation with adhesins further characterized in culture systems as well as animal models. The long term goal of Research Area A is to identify microbial effectors that can be targeted or exploited for therapeutic interventions.
Principal Investigators
Deputy Spokesperson
University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine
Department of Microbial Bioactive Compounds
heike.broetz-oesterhelt
@uni-tuebingen.deWebseite
Director Graduate School IGIM
University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine Tübingen
Cellular and Molecular Microbiology
samuel.wagner
@med.uni-tuebingen.deWebseite
University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine
Microbiology/Biotechnology
Equal Opportunities Officer
University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine Tübingen
Applied Natural Products Genome Mining
nadine.ziemert
@uni-tuebingen.deWebseite
