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Research Area A

A: Bacterial Molecules and Cells

Central question

Which bacterial molecules govern the specific interactions of bacterial cells with other microorganisms and host cells?

Aim

Bacterial fitness and microbial interactions are shaped by multiple factors, including the ability to secrete antimicrobial compounds and to colonize specific niches. Scientists in Research Area A will join forces to identify and isolate from the human microbiome new bacterial strains that produce antimicrobials. The mode of action of these molecules will then be dissected and their ecological role clarified.

In parallel, using a combination of computational, genetic, cellular and biochemical approaches, gene clusters potentially involved in glycopolymer biosynthesis will be identified and their involvement in bacterial adhesion in cooperation with adhesins further characterized in culture systems as well as animal models. The long term goal of Research Area A is to identify microbial effectors that can be targeted or exploited for therapeutic interventions.

Principal Investigators

Prof. Dr.  Heike  Brötz-Oesterhelt

Deputy Spokesperson

University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine
Department of Microbial Bioactive Compounds

+49 7071 29-74706
heike.broetz-oesterhelt@uni-tuebingen.de
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Prof. Dr.  Stephanie  Grond

University of Tübingen
Institute of Organic Chemistry

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Prof. Dr.  Andrei  Lupas

Max Planck Institute for Biology
Proteinevolution

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Prof. Dr.  Samuel  Wagner

Director Graduate School IGIM

University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine Tübingen
Cellular and Molecular Microbiology

+49 7071 29-84238
samuel.wagner@med.uni-tuebingen.de
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Prof. Dr. em.  Wolfgang  Wohlleben

University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine
Microbiology/Biotechnology

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Prof. Dr.  Nadine  Ziemert

Equal Opportunities Officer

University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine Tübingen
Applied Natural Products Genome Mining

+49 7071 29-78841
nadine.ziemert@uni-tuebingen.de
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