Research Area D: Towards Integrative Therapy Concepts
Central question:
How can discoveries from the other areas be harnessed for innovative microbiome-based diagnostic, preventive, and therapeutic strategies?
Aim
Scientists in Research Area D will translate knowledge acquired in sections A, B and C into innovative, microbiome-centered, and personalized strategies of risk stratification, diagnosis, prevention and therapy against antibiotic-resistant bacterial pathogens (ARBPs). Notably, the resistomes of risk patients will be analyzed by metagenome sequencing of fecal samples and used to implement patient-specific therapies.
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Moreover, combined resistome data will be used to adjust general antibiotic stewardship guidelines at the University Hospital Tübingen. In parallel, the commensals, the phages and the host-derived antimicrobial molecules with the capacity to selectively eliminate facultative pathogens from human microbiomes such as those identified in Research Area A, B, and C will be tested as promising agents to prevent infections by ARBPs.
Principal Investigators
![Dr. Meral Esen Portrait Meral Esen](/fileadmin/_processed_/f/5/csm_Meral_Esen-quadratisch_f906103654.png)
![Prof. Dr. Reiner Jumpertz-von Schwartzenberg Portrait Reiner Jumpertz-von Schwartzenberg](/fileadmin/_processed_/4/b/csm_Jumpertz_v_Schwartzenberg_Reiner_quadratisch_2e8a4660ac.jpg)
University Hospital Tübingen
Diabetology, Endocrinology, Nephrology
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![Prof. Dr. Peter Kremsner Portrait Peter Kremsner](/fileadmin/_processed_/a/4/csm_Kremsner_quadratisch_c296487238.jpg)
University of Tübingen
Institute for Tropical Medicine, Travel Medicine, Human Parasitology
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![Prof. Dr. Benjamin Mordmüller Portrait Benjamin Mordmüller](/fileadmin/_processed_/7/b/csm_Mordmueller_quadratisch_64b9a22140.jpg)
University of Tübingen
Institute for Tropical Medicine
Translationale Infectiology and Vaccine Development
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Website
![Prof. Dr. Birgit Schittek Portrait Birgit Schittek](/fileadmin/_processed_/4/4/csm_Schittek_quadratisch_ab20422942.jpg)
University Hospital Tübingen
Immunology and Oncology
Molecular Dermatology
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![Prof. Christoph Stein-Thoeringer](/fileadmin/_processed_/d/2/csm_Stein-Thoeringer_Christoph_a92e30a132.jpg)
Board Member, Coordinator Research Area D
University Hospital Tübingen
Infectious Diseases and Translational Microbiome Sciences
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![Prof. Dr. Dr. Urban Wiesing Portrait Urban Wiesing](/fileadmin/_processed_/d/3/csm_Wiesing_Urban_quadratisch_00c3324324.jpg)
University of Tübingen
Institute for Ethics in Sciences and Humanities
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