skip to main content
Research Area D

Research Area D: Towards Integrative Therapy Concepts

Central question:

How can discoveries from the other areas be harnessed for innovative microbiome-based diagnostic, preventive, and therapeutic strategies?

Aim

Scientists in Research Area D will translate knowledge acquired in sections A, B and C into innovative, microbiome-centered, and personalized strategies of risk stratification, diagnosis, prevention and therapy against antibiotic-resistant bacterial pathogens (ARBPs). Notably, the resistomes of risk patients will be analyzed by metagenome sequencing of fecal samples and used to implement patient-specific therapies.

Moreover, combined resistome data will be used to adjust general antibiotic stewardship guidelines at the University Hospital Tübingen. In parallel, the commensals, the phages and the host-derived antimicrobial molecules with the capacity to selectively eliminate facultative pathogens from human microbiomes such as those identified in Research Area A, B, and C will be tested as promising agents to prevent infections by ARBPs.

Principal Investigators

Portrait Meral Esen
Dr.  Meral  Esen

University Hospital Tübingen
Institute for Tropical Medicine

Meral.Esen@uni-tuebingen.de
Website

Portrait Reiner Jumpertz-von Schwartzenberg
Prof. Dr.  Reiner  Jumpertz-von Schwartzenberg

University Hospital Tübingen
Diabetology, Endocrinology, Nephrology

reiner.jumpertz-vs@med.uni-tuebingen.de
Website

Portrait Peter Kremsner
Prof. Dr.  Peter  Kremsner

University of Tübingen
Institute for Tropical Medicine, Travel Medicine, Human Parasitology

peter.kremsner@uni-tuebingen.de
Website

Portrait Benjamin Mordmüller
Prof. Dr.  Benjamin  Mordmüller

University of Tübingen
Institute for Tropical Medicine
Translationale Infectiology and Vaccine Development

benjamin.mordmueller@uni-tuebingen.de
Website

Portrait Birgit Schittek
Prof. Dr.  Birgit  Schittek

University Hospital Tübingen
Immunology and Oncology
Molecular Dermatology

birgit.schittek@uni-tuebingen.de


Prof. MD  Christoph  Stein-Thoeringer

Universitätsklinikum Tübingen
Klinische Infektiologie und Translationale Mikrobiomforschung

christoph.stein-thoeringer@med.uni-tuebingen.de
Website

Portrait Urban Wiesing
Prof. Dr. Dr.  Urban  Wiesing

University of Tübingen
Institute for Ethics in Sciences and Humanities

urban.wiesing@uni-tuebingen.de
Website