Technology Platforms
The CMFI supports five Technology Platforms with substantial resources. Equipped with cutting-edge technology and specialist staff, they develop and implement new methods. In doing so, they often take new research directions and thus help to shape the working methods of the disciplines. Employees of the University of Tübingen benefit from the resulting services.
QBiC - Quantitative Biology Center
The Quantitative Biology Center (QBiC) provides access to high-through-put (HT) technologies, such as Next Generation Sequencing (NGS) for nucleotide sequencing or mass spectrometry for protein and metabolite analysis. Furthermore, through its integrated concept of opera-tion it complements the service by key expertise in the bioinformatics analysis of the generated data. QBiC also takes care of CMFI data asservation in accordance with a FAIR data management concept.
In addition, the QBiC develops analysis methods and statistic concepts, provides scientific advice, and offers training in bioinformatics and in various high-throughput methods.
Core Facility Genomics
The Core Facility Genomics provides a wide range of next generation sequencing (NGS) methodologies for short- and long-read sequencing, along with tailored solutions for specific research needs. The services prioritize expertise, reliability, and reproducibility, aiming to streamline functional genomics studies. Combining expertise from two specialized labs - human genetics (eukaryotes) and microbial genomics (prokaryotes) - the Core Facility Genomics offers complementary resources, including biosafety and automation capabilities. Beyond sequencing, it supports genomic research, microbial studies, model systems, and data science, focusing on custom solutions and advanced support for projects of all sizes.
The Core Facility Genomics supports Next Generation Sequencing (NGS) projects within the CMFI with scientific expertise in all relevant aspects: experimental design, sample handling, nucleic acid extraction, (custom) library preparation and the most recent short read and long read sequencing technologies and analysis methods.
NatResource – Natural Product Resource Center
NatResource, Tübingen’s natural product center, connects natural product isolating research groups (Microbiology, Chemistry, and Pharmacy) with research groups characterizing the bioactive molecules (Biology and Medical Faculty).
Natural product research in Tübingen covers the identification of novel producer strains, compound purification and structure elucidation, analysis of biosynthetic pathways, and characterization of biological activities on the molecular level.
Natural products are a versatile source of bioactive compounds. More than two thirds of all antibiotic classes in therapeutic application are derived from natural products, and natural products are also widely applied in tumor therapy.
Led by
GRCT – Gnotobiotic Research Center Tübingen
The Gnotobiotic Research Center Tübingen (GRCT) provides the infrastructure for in vivo simulations of microbiome-host interactions with defined and standardized microbiome composition. Project-specific personnel and resources of the GRCT are co-funded by the CMFI.
CMFI Clinical Trials Platform
One of our major goals is to fight infections caused by pathogens with decolonizing agents and commensals from the microbiome. The Clinical Trials Platform enables the testing of promising therapeutic methods by conducting controlled colonization experiments in humans. The Clinical Trial Platform was established for malaria vaccine efficacy studies and adapted to the needs of the CMFI.
