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Prof. Dr. Hannes Link

Coordinator Research Area A


University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine
Bacterial Metabolomics



Research Interest

Hannes Link’s research interests include metabolic networks and the interactions between metabolites and regulators of gene expression. The aim of his research is to engineer bacterial metabolism for biotechnological and medical applications. This work includes the development of metabolomics methods to quantify metabolites and metabolic fluxes.

Website Research Group Link


About Hannes Link

Hannes Link has been appointed to the professorship ‘Bacterial Metabolomics’ at the University of Tübingen in October 2020. He studied chemical-engineering at the Technical University Munich from 2000-2005 and received his PhD from the Department of Biochemical Engineering of the TU Munich in 2009. After 5 years as a postdoc with Prof. Uwe Sauer at the ETH Zurich, he headed an Emmy Noether research group at the MPI for Terrestrial Microbiology in Marburg from 2015-2020. He has been a member of the CMFI Board and coordinator of Research Area A since 2023.


Lo Presti L, Link H. (2024) Mobile CRISPRi moves through the complexity of bacterial genetics. Cell Rep Methods. 4(1). doi: 10.1016/j.crmeth.2024.100697.

Schramm T, Lubrano P, Pahl V, Stadelmann A, Verhülsdonk A, Link H. (2023) Mapping temperature-sensitive mutations at a genome scale to engineer growth switches in Escherichia coli. Mol. Syst. Biol. doi: 10.15252/msb.202311596.

Schwedt I, Collignon M, Mittelstädt C, Giudici F, Rapp J, Meißner J, Link H, Hertel R, Commichau FM. (2023) Genomic adaptation of Burkholderia anthina to glyphosate uncovers a novel herbicide resistance mechanism. Environ Microbiol Rep. doi: 10.1111/1758-2229.13184.

Goldfinger V, Spohn M, Rodler JP, Sigle M, Kulik A, Cryle M, Rapp J, Link H, Wohlleben W, Stegmann E. (2023) Metabolic engineering of the shikimate pathway in Amycolatopsis strains for optimized glycopeptide antibiotic production. Metab Eng. 25:S1096-7176(23)00079-4. doi: 10.1016/j.ymben.2023.05.005.

Hauke M, Metz F, Rapp J, Faass L, Bats SH, Radziej S, Link H, Eisenreich W, Josenhans C. (2023) Helicobacter pylori Modulates Heptose Metabolite Biosynthesis and Heptose-Dependent Innate Immune Host Cell Activation by Multiple Mechanisms. Microbiol Spectr. e0313222. doi: 10.1128/spectrum.03132-22.

Farke N, Schramm T, Verhülsdonk A, Rapp J, Link H. (2023) Systematic analysis of in-source modifications of primary metabolites during flow-injection time-of-flight mass spectrometry. Anal. Biochem. 664: 115036. doi: 10.1016/j.ab.2023.115036.

Burkhardt M, Rapp J, Menzel C, Link H, Forchhammer K. (2023) The Global Influence of Sodium on Cyanobacteria in Resuscitation from Nitrogen Starvation. Biology (Basel) 12(2):159. doi: 10.3390/biology12020159.

Meißner J, Schramm T, Hoßbach B, Stark K, Link H, Stülke J. (2022) How To Deal with Toxic Amino Acids: the Bipartite AzlCD Complex Exports Histidine in Bacillus subtilis. J Bacteriol. 204(12): e0035322. doi: 10.1128/jb.00353-22.

Radoš D, Donati S, Lempp M, Rapp J, Link H. (2022) Homeostasis of the biosynthetic E. coli metabolome. iScience 25(7). doi: 10.1016/j.isci.2022.104503.

Wang CY, Lempp M, Farke N, Donati S, Glatter T, Link H. (2021) Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coliNat Commun 12:4929. doi: 10.1038/s41467-021-25142-0.


You can find a full list of publications here