Evolutionary genomics of microbial pathogens
Sprecher: Felix Key (Max-Planck-Institut für Infektionsbiologie)
Gastgeberin: Lisa Maier
Datum & Uhrzeit: 24.10.2024 | 12:30 – 14:00 Uhr
Ort: Hörsaal 3M07, GUZ
Öffentliche Veranstaltung. Keine Anmeldung erforderlich.
Abstract:
Microbes are shaped by their evolutionary history, which provides them the genomic framework to cause disease. Experimental, analytical and technological innovation enables today genomic reconstruction at unprecedented detail. The Key lab aims to uncover the genetic mechanisms and phenotypic variation that underlay emergence, transmission and adaptation of pathogens. We use a systems approach collecting data directly from the host to trace microbial evolution in vivo on dramatically different timescales – ranging from a few weeks to thousands of years. Here I will present work of my lab using ancient metagenomic datasets as well as colony-based sequencing to reconstruct the evolutionary history of human pathogens and identify genetic changes associated with infection. Investigating the genomic footprint of pathogens from the past and the presence holds promise to improve our capacities for disease prevention and intervention.