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– VERSCHOBEN – How bacteria generate functional diversity – From cell differentiation to virulence and back

02.12.2021 12:30 Uhr Mikrobiologisches Kolloquium Urs Jenal

– Dieser Vortrag wurde aufgrund der aktuellen pandemischen Entwicklungen auf den 05.05.2022 verschoben –

Sprecher/-in: Urs Jenal (Universität Basel)

Gastgeber/-in: Samuel Wagner (CMFI)

Ort: Hybridevent

  • Hörsaal N2, Hörsaalzentrum Morgenstelle, Auf der Morgenstelle 16, 72076 Tübingen


  • Online via Zoom


Bacteria are masters in adapting to different environments by gradually adjusting
their physiology and resilience or by functionally diversifying through cell
differentiation processes. Distinct behavioral programs either result from cell
polarity and asymmetric divisions or arise through binary decisions producing
functionally heterogenous populations. In this lecture, I will discuss how bacterial
cell fate programs are determined by the small signaling molecule c-di-GMP, a
member of a growing family of highly versatile nucleotide-based signaling molecules
that control important biological processes in bacteria and eukaryotes. I will explain
how c-di-GMP oscillations determine cell fate and behavior in different nonpathogenic
and pathogenic bacteria and I will present examples for how stochastic
distributions of c-di-GMP generate population heterogeneity and memory effects
during developmental transitions.