Novel virulence factors and secretion mechanisms of intracellularly adapted Salmonella enterica serovars
Sprecher: Tobias Geiger (LMU München)
Gastgeber: Samuel Wagner (IMIT)
Ort: 3M07, GUZ
Datum & Uhrzeit: 15.06.2023, 12:30 – 14:00 Uhr
Adapted to an intracellular lifestyle, pathogenic Salmonella enterica owns a plethora of tightly regulated virulence factors, which when required, are expressed and subsequently secreted by specific secretion systems to facilitate bacterial infection. Besides classical virulence factors such as toxins or adhesins, Salmonella enterica also takes advantage of metabolic enzymes capable to degrade various substrates important for colonization. Here, we are interested in chitinase A, a novel virulence factor that specifically promotes invasion into polarized intestinal epithelial host cells. Interestingly, chitinase A is secreted through a dedicated protein secretion system, also referred to as a Type 10 Secretion System, that has been initially described in typhoidal Salmonella enterica serovar Typhi. The genomes of typhoidal serovars contain additional pathogenic islands that contribute to their increased virulence. One of these islands is Salmonella pathogenicity island 18 (SPI18) which includes a gene that encodes for a cytolysin. So far this toxin has not been described in greater detail and is therefore under investigation for its relevance to establish infection in the context of intracellularly adapted typhoidal Salmonella serovars.