Novel ways utilized by Staphylococcus aureus to modulate host innate immunity

Sprecher: Markus Bischoff (Universität des Saarlandes)

Titel: Novel ways utilized by Staphylococcus aureus to modulate host innate immunity

Gastgeberin: Christiane Wolz (CMFI)

Datum & Uhrzeit: 02.03.2023, 12:30–14:00 Uhr

Ort: Hörsaalzentrum Morgenstelle, Raum 7E02
        Auf der Morgenstelle 16
        72076 Tübingen
 

Abstract:
The Gram-positive bacterium Staphylococcus aureus is a versatile human pathogen and a common cause for implant-associated infections. Part of its success as human pathogen is its ability to interact with the host and to modulate the host innate immune response in many ways. In this guest lecture, I will talk about some recently identified novel ways of this opportunistic pathogen to modulate/escape host innate immunity. Specifically, I will show you that the S. aureus exoprotein Eap interferes with wound healing and neutrophil extracellular trap formation, and that the low molecular weight protein phosphatases produced by this bacterium contribute to intramacrophage survival and infectivity. A third aspect of my presentation will be the impact of host factors on the initial adhesion events of S. aureus to intravascular devices.

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