Brochado Lab

The Brochado lab studies how bacteria cope with drugs in their environment with goal is to expose druggable features to aid treatment design. In parallel, our overarching goal is to gain biological insight into how bacteria operate. We combine basic microbiology, high-throughput screening and systems biology approaches to tackle our questions with a comprehensive perspective that extends beyond conventional drug targets. Current projects in our lab focus on i) systematically understanding fast appearing multi-faceted intrinsic antibiotic resistance mutations in Enterobacteriacea, ii) uncovering the molecular mechanism of synergies against difficult-to-treat pathogens, such as Pseudomonas aeruginosa, iii) developing systematic approaches to unravel drug transport regulation in Gram-negative bacteria, and iv) investigating the interface between bacterial immunity (phage defence) and antibiotic response. Ultimately, we believe that bringing our molecular understanding on how bacteria cope with their environment to a systems level will enable efficient strategies to fight the spread of antibiotic resistance.

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